Efficacy of Pazopanib With or Without Gemcitabine in Patients ... | 合法藥品大搜索

2020年12月23日—ImportancePazopanibandgemcitabinehaveshowngoodtolerability,albeitmodestsingle-agentactivityinpretreatedsofttissuesarcoma.A ...

Key Points

Question What is the tolerability and efficacy of pazopanib and gemcitabine compared with pazopanib alone in pretreated soft tissue sarcoma?

Findings In this randomized clinical trial with 86 eligible patients, the combination of gemcitabine and pazopanib showed a significantly higher progression-free survival rate at 12 weeks (primary end point) compared with pazopanib alone.

Meaning The combined regimen of gemcitabine and pazopanib seems to have clinical activity and should be further evaluated.

Importance Pazopanib and gemcitabine have shown good tolerability, albeit modest single-agent activity in pretreated soft tissue sarcoma. A combined regimen to improve outcomes is required.

Objective To determine the efficacy of gemcitabine and pazopanib compared with pazopanib alone.

Design, Setting, and Participants This multicenter...

Pazopanib in advanced soft tissue sarcomas | 合法藥品大搜索

由 ATJ Lee 著作 · 2019 · 被引用 27 次 — Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue ... Read More

Pazopanib in sarcomas: expanding the PALETTE | 合法藥品大搜索

EFFICACY OF PAZOPANIB IN SARCOMA PATIENTS · 由 BA Wilky 著作 · 2013 · 被引用 23 次 — Pazopanib has been tested in sarcoma patients in a phase II and phase III study, and ... Read More

Pazopanib in the management of advanced soft tissue sarcomas | 合法藥品大搜索

Pazopanib expLorEd in sofT-Tissue sarcoma – a phasE III study · 由 LD Cranmer 著作 · 2016 · 被引用 24 次 — Table 1. Clinical studies of pazopanib enrolling soft tissue sarcoma patients ... Read More

Pazopanib for metastatic soft | 合法藥品大搜索

由 WTA van der Graaf 著作 · 2012 · 被引用 1533 次 — Background: Pazopanib, a multitargeted tyrosine kinase inhibitor, has single-agent activity in patients with advanced non-adipocytic soft-tissue ... Read More

Pazopanib monotherapy in the treatment of pretreated ... | 合法藥品大搜索

由 HJ Kim 著作 · 2018 · 被引用 12 次 — Pazopanib monotherapy in the treatment of pretreated, metastatic uterine sarcoma: a single-center retrospective study. J Gynecol Oncol. 2018 Jan;29(1):e3. doi: ... Read More

Pazopanib | 合法藥品大搜索

由 S Sleijfer 著作 · 2009 · 被引用 650 次 — PURPOSE Given the importance of angiogenesis in soft tissue sarcoma (STS), pazopanib, an oral angiogenesis inhibitor that targets vascular endothelial ... Read More

Pazopanib for metastatic soft | 合法藥品大搜索

由 S Koca 著作 · 2021 · 被引用 1 次 — Pazopanib for metastatic soft-tissue sarcoma: A multicenter retrospective study. J Oncol Pharm Pract. 2021 Apr;27(3):541-546. doi: 10.1177/1078155220924075 ... Read More

Pazopanib Shows Promise for Soft Tissue Sarcomas ... | 合法藥品大搜索

2020年9月9日 — For children and adults with advanced soft tissue sarcoma, adding pazopanib (Votrient) to chemotherapy and radiation may be a new treatment ... Read More

Pazopanib for metastatic soft | 合法藥品大搜索

由 WTA van der Graaf 著作 · 2012 · 被引用 1533 次 — Pazopanib, a multitargeted tyrosine kinase inhibitor, has single-agent activity in patients with advanced non-adipocytic soft-tissue sarcoma. Read More

Efficacy of Pazopanib With or Without Gemcitabine in Patients ... | 合法藥品大搜索

2020年12月23日 — Importance Pazopanib and gemcitabine have shown good tolerability, albeit modest single-agent activity in pretreated soft tissue sarcoma. A ... Read More

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