Olopatadine hydrochloride suppresses the rebound ... | 合法藥品大搜索

由TTamura著作·2005·被引用27次—Background:Olopatadinehydrochloride(olopatadine;Allelock)isoneofthesecond-generationantihistaminesthataretreatedforallergicdisorderssuchas ...

Background: Olopatadine hydrochloride (olopatadine; Allelock) is one of the second-generation antihistamines that are treated for allergic disorders such as rhinitis, urticaria and eczema dermatitis. Olopatadine has recently been shown to have inhibitory effects on the chronic contact hypersensitivity induced by repeated application of oxazolone in mice. Although topical steroids have widely been prescribed for atopic dermatitis, a relapse often occurs within several days after discontinuation of their prolonged use.

Objectives: We investigated the possible efficacy of olopatadine against the relapse after discontinuation of prolonged use of topical prednisolone in the Balb/c mice with oxazolone-induced chronic contact hypersensitivity.

Methods: Mice with the chronic contact hypersensitivity induced by repeated application of oxazolone were treated with olopatadine as a sequenti...