NegGram Caplets (Nalidixic Acid): Uses | 合法藥品大搜索

NegGram(nalidixicacid,USP)isindicatedforthetreatmentofurinarytractinfectionscausedbysusceptiblegram-negativemicroorganisms,includingthemajority ...

Following oral administration, NegGram is rapidly absorbed from the gastrointestinal tract, partially metabolized in the liver, and rapidly excreted through the kidneys. Unchanged nalidixic acid appears in the urine along with an active metabolite, hydroxynalidixic acid, which has antibacterial activity similar to that of nalidixic acid. Other metabolites include glucuronic acid conjugates of nalidixic acid and hydroxy nalidixic acid, and the dicarboxylic acid derivative. The hydroxy metabolite represents 30 percent of the biologically active drug in the blood and 85 percent in the urine. Peak serum levels of active drug average approximately 20 mcg to 40 mcg per mL (90 percent protein bound), one to two hours after administration of a 1 g dose to a fasting[1] normal individual, with a half-life of about 90 minutes. Peak urine levels of active drug average approximately 150 mcg to ...