Clinical overview of prazosin in the treatment of prostatic ... | 合法藥品大搜索

由EMilroy著作·1990·被引用9次—Prazosiniswellknowntomostphysiciansasaneffectiveantihypertensivemedication,butitstherapeuticvalueinmanycasesofbenignprostatichyperplasia ...

Prazosin is well known to most physicians as an effective antihypertensive medication, but its therapeutic value in many cases of benign prostatic hyperplasia (BPH) may be unfamiliar to many. Prostate problems are among the most common medical conditions facing older men, with BPH appearing in more than 50% of men over the age of 50 years and in 90% of those over 80 years of age. About 10% of men over the age of 40 undergo surgery for the condition. Research in the past 15 years has revealed that smooth muscle contractions in the enlarged prostate are controlled by stimulation of the alpha 1-receptors in the tissue. This discovery has provided the rationale for administering drugs to block the stimulation of the alpha 1-receptors to relieve the obstructive and irritative symptoms of BPH. Prazosin was an early candidate for such medication because of its highly selective alpha 1-blockade and its well-documented safety record. Ea...