Sunitinib: the antiangiogenic effects and beyond | 合法藥品大搜索

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由 T Guo 著作 · 2009 · 被引用 88 次 — Sunitinib resistance in GIST shares similar pathogenetic mechanisms identified in imatinib failure, with acquisition of secondary mutations in ... Read More

由 WL Wang 著作 · 2011 · 被引用 78 次 — Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor. Cancer Chemother Pharmacol. 2011 Jan;67 Suppl 1:S15-24. doi: ... Read More

由 KJ Gotink 著作 · 2011 · 被引用 266 次 — We analyzed tumor sunitinib levels in mice and patients and studied sensitivity and resistance mechanisms to sunitinib. Experimental design: ... Read More

由 C Le Tourneau 著作 · 2007 · 被引用 182 次 — In vitro, sunitinib inhibited the growth of cell lines driven by VEGF, SCF, and PDGF and induced apoptosis of human umbilical vein endothelial cells (Mendel et al ... Read More

Mechanism of action · 由 Z Hao 著作 · 2016 · 被引用 46 次 — Sunitinib has also been implicated in enhancing cancer invasiveness and metastasis. Mechanisms of resistance are poorly ... Read More

Mechanism of action — Mechanism of action[edit]. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). These ... Read More

Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth ... Read More

由 Z Hao 著作 · 2016 · 被引用 46 次 — Mechanistically, sunitinib inhibits multiple receptor tyrosine kinases, especially those involved in angiogenesis, that is, vascular endothelial ... Read More

由 G Aparicio-Gallego 著作 · 2011 · 被引用 110 次 — Sunitinib induces an increase in the production of amylase and/or lipase by the exocrine pancreas (4, 8), probably in response to necrosis or ... Read More