A Comparison of Varying α-Blockers and Other ... | 合法藥品大搜索

由CRChapple著作·2005·被引用72次—Oneolderstudycomparedalfuzosin(2.5mgt.i.d)withprazosin(2mgb.i.d)for3...increaseourunderstandingofthemechanismsofactionofα-blockersoverall.

α1-Adrenoceptor antagonists are now well established as the most common treatment for lower urinary tract symptoms (LUTS) suggestive of bladder outflow obstruction associated with benign prostatic hyperplasia. Both α1-adrenoceptor antagonists and 5α-reductase inhibitors are accepted treatments for LUTS, but with finasteride this applies only to patients with clinically enlarged prostates, whereas α1-adrenoceptor antagonists are considered to be appropriate treatment for all patients, irrespective of prostate size. Systematic analyses of placebo-controlled studies show that commonly used α1-blockers are significantly superior to placebo in improving urinary flow and reducing symptoms. Efficacy of α-blockers appears to be well maintained over time, and there is no evidence of tolerance or tachyphylaxis to α1-blockade after 6–12 months usage. Direct comparative trials show that, in the short term, α1-adrenoceptor antagonists are more effective than finast...