The effect of airway alkalization by nebulized sodium ... | 合法藥品大搜索

由AKis著作·2012·被引用4次—Theeffectofairwayalkalizationbynebulizedsodiumbicarbonateonairwayblood...airwaypH,couldimproveabsorptionofinhaledcationicbronchodilators.

Background: The airway acidifies in a variety of inflammatory lung diseases as measured by exhaled breath condensate (EBC). We have demonstrated in vitro that alkalization improves absorption of cationic bronchodilators, such as albuterol and tiotropium, both in airway epithelia and smooth muscle cells; however, the rationale of airway alkalization therapy is not fully understood.

Objective: The purpose of the study was to determine the effect of nebulized sodium bicarbonate (NaHCO3) solution on airway vascular smooth muscle function.

Methods: Ten healthy non-smoker volunteers participated in the study. To assay airway pH, EBC was collected pre- and post-administration of 4.2% NaHCO3 (pH=8.4). NaHCO3 induced CO2 production was evaluated with a real-time mass spectrometer gas analyzer by me...