Total synthesis of vinblastine, vincristine | 合法藥品大搜索

由 MA Jordan 著作 · 1985 · 被引用 147 次 — Vinblastine was nine times more potent than the weakest derivative, vinepidine, in B16 melanoma cells. In L-cells, vinblastine completely inhibited growth at 40 ... Read More

由 MM Mareel 著作 · 1982 · 被引用 36 次 — Inhibition of the invasiveness of MO4 mouse fibrosarcoma cells by the vinca alkaloid, vinblastine (VLB), vincristine (VCR) and vindesine (VDS), ... Read More

由 H Ishikawa 著作 · 2009 · 被引用 290 次 — Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. J Am Chem Soc. Read More

由 SM Howard 著作 · 1980 · 被引用 44 次 — The Vinca alkaloids vinblastine, vincristine, and vindesine were compared for their capacity to arrest L1210 cells in mitosis and for their effect on the ... Read More

Pharmacology[edit] ... Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. ... It binds tubulin, thereby inhibiting the assembly of microtubules ... Read More

Vinblastine and vincristine are alkaloids derived from the periwinkle plant Catharanthus roseus. These compounds have cell cycle-specific activity in the M ... Read More

2018年3月28日 — The chemical structures of vinblastine and vincristine are quite complex and the mechanisms by which the plant produces these chemicals are not ... Read More

Changes in the Structure of Vincristine · 由 P Keglevich 著作 · 2012 · 被引用 72 次 — Vinblastine (1) and vincristine (2) are dimeric alkaloids (Figure 1) isolated from the Madagaskar periwinkle plant ... Read More

由 H Ishikawa 著作 · 2009 · 被引用 290 次 — Vinblastine (1) and vincristine (2) are the most widely recognized members of the class of bisindole alkaloids as a result of their clinical use as ... Read More