Rythmol (Propafenone): Uses, Dosage | 合法藥品大搜索

PropafenoneisaClass1Cantiarrhythmicdrugwithlocalanestheticeffects,andadirectstabilizingactiononmyocardialmembranes.Theelectrophysiological ...

Included as part of the PRECAUTIONS section.

Propafenone has caused new or worsened arrhythmias. Such proarrhythmic effects include sudden death and life-threatening ventricular[1] arrhythmias such as ventricular fibrillation[2], ventricular tachycardia[3], asystole[4] and torsade de pointes. It may also worsen premature ventricular contractions or supraventricular arrhythmias, and it may prolong the QT interval. It is therefore essential that each patient given RYTHMOL be evaluated electrocardiographically prior to and during therapy to determine whether the response to RYTHMOL supports continued treatment. Because propafenone prolongs the QRS interval in the electrocardiogram[5], changes in the QT interval are difficult to interpret [see CLINICAL PHARMACOLOGY[6]].

In a U.S. uncontrolled, open label, multic...