A case series of hospitalized patients with elevated digoxin ... | 合法藥品大搜索

由PEMarik著作·1998·被引用65次—Conclusions:Elevateddigoxinlevelsandclinicaltoxicityremainsacommonadversedrugreaction.Elderlypatients,particularlythosewithimpairedrenal ...

Purpose: Although there is renewed enthusiasm for the use of digoxin in patients with heart failure, current dosing guidelines are based on a nomogram published in 1974. We studied the incidence of and risk factors for elevated digoxin levels in patients admitted to a community hospital, and compared their dosage regimens to published guidelines.

Subjects and methods: We reviewed the charts of all patients who had serum digoxin levels greater than 2.4 ng/mL during a 6-month period. We collected demographic and clinical data, indications for digoxin use, digoxin dosage, concurrent medications, laboratory data, and clinical and electrocardiographic features of digoxin toxicity.

Results: Of the 1,433 patients with digoxin assays, 115 (8%) patients had elevated levels. Of the 82 patients with complete records and correctly timed digoxin levels, 59 (72%) had electrocardiographic or c...