A randomized trial of 7 | 合法藥品大搜索

由MHKollef著作·2012·被引用178次—Arandomizedtrialof7-daydoripenemversus10-dayimipenem-cilastatinforventilator-associatedpneumonia.CritCare.2012Nov13;16(6):R218.doi: ...

Introduction: The aim of this study was to compare a 7-day course of doripenem to a 10-day course of imipenem-cilastatin for ventilator-associated pneumonia (VAP) due to Gram-negative bacteria.

Methods: This was a prospective, double-blinded, randomized trial comparing a fixed 7-day course of doripenem one gram as a four-hour infusion every eight hours with a fixed 10-day course of imipenem-cilastatin one gram as a one-hour infusion every eight hours (April 2008 through June 2011).

Results: The study was stopped prematurely at the recommendation of the Independent Data Monitoring Committee that was blinded to treatment arm assignment and performed a scheduled review of data w...