新藥充電站16Tolectin（Tolmetin） | 合法藥品大搜索

Tolmetin，商品名：Artrocaptin(ES);Tolectin用途：Treatmentofrheumatoidarthritisandosteoarthritis,ju.

Tolmetin，商品名：Artrocaptin (ES);Tolectin

用途：

Treatment of rheumatoid arthritis and osteoarthritis, juvenile rheumatoid arthritis

治療風濕性關節炎、骨關節炎，幼年型風濕性關節炎

機轉：

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.

Other proposed mechanisms not fully elucidated (and possibly contributing to the anti-inflammatory effect to varying degrees) include inhibiting chemotaxis, altering lymphocyte activity, inhibiting neutrophil aggregation/activation, and decreasing proinflammatory cytokine levels.

其實就是NSAID，不過比較不同的，他的結構並非是pyrine，也不是水楊酸，也沒有indene，也看不到proprionic acid，所以可以用在對於aspirin或是ibuprofen及cataflam反應比較差的病患。

合成過程：

治療劑量：

Inflammation, arthritis: Oral: 400 mg 3 times/day; usual dose: 600 mg to 1.8 g/day; maximum: 1.8 g...