Meglitinide | 合法藥品大搜索

Meglitinidesorglinidesareaclassofdrugsusedtotreattype2diabetes.Contents.1Drugs;2Sideeffects;3Mechanismofaction;4References ...

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Chemical substance

Meglitinides or glinides are a class of drugs used to treat type 2 diabetes.[1]

Repaglinide (trade name Prandin)[2] gained US Food and Drug Administration approval in 1997.

Other drugs in this class include nateglinide (Starlix)[3] and mitiglinide (Glufast).

Side effects include weight gain and hypoglycemia. While the potential for hypoglycemia is less than for those on sulfonylureas,[citation needed] it is still a serious potential side effect that can be life-threatening. Patients on this medication should know the signs and symptoms of hypoglycemia and appropriate management.

Repaglinide caused an increased incidence in male rats of benign adenomas (tumors) of the thyroid and liver.[2] No such effect was seen with another drug of this class, nateglinide.[3]

A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortalit...