Effect of mannitol and furosemide on plasma osmolality and ... | 合法藥品大搜索

由KThenuwara著作·2002·被引用75次—Thecombinationofmannitolandfurosemideresultedingreaterreductionofbrainwatercontentthandidmannitolalone.Furosemideenhancedtheeffectof ...

Background: Mannitol and furosemide are used to reduce increased intracranial pressure (ICP) and to reduce brain bulk during neurosurgery. One mechanism by which these changes might occur is via a reduction in brain water content. Although mannitol and furosemide are commonly used in combination, there has been no formal evaluation of the interactive effects of these two drugs on brain water. The effect of mannitol and furosemide alone and in combination on water content of normal rat brain was examined.

Methods: The lungs of rats anesthetized with halothane were mechanically ventilated to maintain normal physiologic parameters. After baseline measurement of plasma osmolality, mannitol (1, 4, or 8 g/kg), furosemide (2, 4, or 8 mg/kg), or a combination of furosemide (8 mg/kg) and manni...