藥學雜誌電子報128期 | 合法藥品大搜索

2016年9月30日—Penicillin(PEN)和cephalosporin(CEPH)引起嚴重立即型過敏...四代CEPH：ceftriaxone、ceftazidime、cefepime等則與PEN無交叉過敏風險10。

Chi-Yuan Cheng, Yi-Cheng Chen, Chi-Hua Chen Department of Pharmacy, Chang Gung Memorial Hospital, Linkou

The incidence of anaphylaxis to penicillins and cephalosporins is very rare. Allergy to penicillins and cephalosporins is caused mainly by reactions to the side chains of the molecules and less commonly to the β-lactam ring. Up to 90% of penicillin allergy individuals are able to tolerate penicillins, because majority of these patients dont have a true penicillin allergy, namely IgE-mediated reactions. Penicillin skin test (PST) is the most reliable method for evaluating IgE-mediated penicillin allergy; however, the result of diluted penicillin G solution as a reagent for PST is questionable. The overall cross allergy between penicillins and cephalosporins in individuals who report a penicillin allergy is approximately 1% and up to 2.55% in those with a confirmed penicillin allergy. For penicillin-allergic patients, the ...