Fluorouracil: Uses | 合法藥品大搜索

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Mechanism of action — Mechanism of action[edit]. 5-FU acts in several ways, but principally as a thymidylate synthase (TS) inhibitor. Interrupting the ... Read More

由 DB Longley 著作 · 2003 · 被引用 4380 次 — 5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led ... Read More

由 M Inaba 著作 · 1998 · 被引用 27 次 — Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells. Biol Pharm Bull. 1998 Jun;21(6):569-73. doi: 10.1248/bpb.21.569. Read More

由 F Tanaka 著作 · 2000 · 被引用 168 次 — In this article, the history, mechanism of anti-tumor activity, and clinical use of oral chemotherapy using 5-fluorouracil (5-FU) derivative chemotherapeutic ... Read More

由 N Zhang 著作 · 2008 · 被引用 458 次 — 5-FU is a pyrimidine analogue that can be misincorporated into RNA and DNA in place of uracil or thymine. The interference with the normal biosynthesis or ... Read More

Mechanism of Action · 由 J Casale 著作 · 2020 · 被引用 3 次 — After ingestion or topical application, 5-FU enters cells via a facilitated transport mechanism and is converted to fluorodeoxyuridine ... Read More

Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because ... Read More

由 T Suetsugu 著作 · 2021 — Three mechanisms of 5FU action have been proposed: DNA uptake (8), RNA uptake (9) and the inhibition of thymidine synthase (TS) leading to ... Read More

2000年9月30日 — The antineoplastic activity of fluorouracil (5-FU) is improved by biochemical modulation[2,3] and when administered as a continuous infusion.[4] ... Read More