Cholecalciferol, Calcitriol | 合法藥品大搜索

由JKendrick著作·2017·被引用35次—WeexaminedtheeffectofcalcitriolversuscholecalciferolsupplementationonvascularendothelialfunctioninpatientswithCKD.

Background and objectives High circulating vitamin D levels are associated with lower cardiovascular mortality in CKD, possibly by modifying endothelial function. We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD.

Design, setting, participants, & measurements We performed a prospective, double-blind, randomized trial of 128 adult patients with eGFR=15–44 ml/min per 1.73 m2and serum 25-hydroxyvitamin D level <30 ng/ml at the University of Colorado. Participants were randomly assigned to oral cholecalciferol (2000 IU daily) or calcitriol (0.5 μg) daily for 6 months. The primary end point was change in brachial artery flow-mediated dilation. Secondary end points included changes in circulat...