Long | 合法藥品大搜索

CMAJ. 2014 Oct 21; 186(15): 1148–1152.

Division of Infectious Diseases (Parameswaran) and Division of Pulmonary, Critical Care and Sleep Medicine (Sethi), Department of Medicine, University at Buffalo, The State University of New York, Buffalo, NY; Veterans Affairs Western New York Healthcare System (Parameswaran, Sethi), Buffalo, NY.

Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by worsening respiratory symptoms, which are almost always accompanied by an increase in airway inflammation.1–3 The majority of these exacerbations are caused by microbial infection.4 By current estimates, about 50% of exacerbations are caused by bacteria, either alone or in combination with viruses.4 Before 1970, multiple attempts were made to test the hypothesis that prophylactic antibiotics can reduce the frequency of COPD exacerbations. Unfortunately, the trials were small, with differ...