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由賴珠煌著作·2003—乙內醯胺酶；乙內醯胺酶抑制劑；廣效乙內醯胺酶；乙內醯胺類抗生素；抗生素抗藥性；β-Lactamases；β-Lactamaseinhibitors；Extendedspectrum ...

As the most widespread resistance mechanism to antibiotics, β -lactamases readily and efficiently hydrolyze β -lactam rings that effectively inactivate the inhibitory function of the β -lactam antibiotics, such as the penicillians and the cephalosporins. Over forty structurally different β -lactarn compounds are available in more than seventy formulations and the majority of them are currently prescribed for medical use in hospitals. β -Lactam antibiotics are well tolerated by humans with, amazingly, few side effects . They interact specifically with their bacterial target, the DD-peptidase. The outstanding number of β -lactamases produced by bacteria represents a serious threat to the clinical utility of β -lactams. The discovery of β -lactamase inhibitors was thought to solve, in part at least, the problem of resistance. Unfortunately, bacteria have evolved new mechanisms of re...