Meropenem | 合法藥品大搜索

由JLBlumer著作·1997·被引用55次—Meropenemisanewbeta-lactamantibioticbelongingtothecarbapenemclass.Itdiffersstructurallyfromimipenem,thefirstcarbapenemtobemarketed, ...

Meropenem is a new beta-lactam antibiotic belonging to the carbapenem class. It differs structurally from imipenem, the first carbapenem to be marketed, by possessing a 1-beta-methyl group on the carbapenem moiety and a substituted 2 side chain. Meropenem is relatively stable to human dehydropeptidase-I (DHP-I), and therefore, unlike imipenem, it does not need to be administered with a DHP-I inhibitor such as cilastatin. Meropenem has an ultra-broad spectrum of antibacterial activity which encompasses Gram-positive and Gram-negative aerobes and anaerobes, including many strains resistant to other antibacterials. Compared to imipenem, meropenem is more active against Enterobacteriaceae and Pseudomonas aeruginosa and a little less active against some Gram-positive cocci. Meropenem is susceptible to few clinically important beta-lactamases. Meropenem exhibits a linear pharmacokinetic profile which shows predictable age and disease...