Quinine and Quinidine | 合法藥品大搜索

Quinine and quinidine are both arylaminoalcohols.

Quinine acts primarily on the erythrocytic stage of human malarias with little parasiticidal effect on sporozoites, hepatic stages, or gametocytes of P. falciparum. 

The asexual stages of P. ovale   are the most vulnerable to quinine, followed by P. vivax, P. malariae and then P. falciparum. Quinine has some gametocytocidal activity for P. vivax and P. malariae,

The mechanism of action is interference with the parasite�s ability to digest haemoglobin. Quinine and quinidine also inhibit the spontaneous formation of beta-haematin (haemozoin or malaria pigment) which is a toxic product of the digestion of haemoglobin by parasites.

Quinine is rapidly and completely absorbed. The clearance of quinine varies between 1.2-4 ml/min/kg and the mean elimination half-life is 10- 12 hours. Clearance may be ...