Low-molecular | 合法藥品大搜索

Genericsandbiosimilars—Averagemolecularweight:heparinisabout15kDaandLMWHisabout4.5kDa.Lessfrequentsubcutaneousdosingthan ...

Anticoagulant medication

Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications.[1] They are used in the prevention of blood clots and treatment of venous thromboembolism (deep vein thrombosis and pulmonary embolism) and in the treatment of myocardial infarction.

Heparin is a naturally occurring polysaccharide that inhibits coagulation, the process that leads to thrombosis. Natural heparin consists of molecular chains of varying lengths, or molecular weights. Chains of varying molecular weights, from 5000 to over 40,000 Daltons, make up polydisperse pharmaceutical-grade heparin.[2] LMWHs, in contrast, consist of only short chains of polysaccharide. LMWHs are defined as heparin salts having an average molecular weight of less than 8000 Da and for which at least 60% of all chains have a molecular weight less than 8000 Da. These are obtained by various methods of f...