Vancomycin Mechanism of Action | 合法藥品大搜索

Vancomycin[1] (brand name: Vancocin®) is a glycopeptide antibiotic with a history that can be traced back to the 1950s when it was discovered in soil produced by the organism Streptomyces orientalis. [1]

Vancomycin protected the nutrient supply needed by Streptomyces orientalis by creating and dispersing the substance, destroying many of the other bacteria species that may enter its territory. After discovering that vancomycin had this activity, infectious disease researchers began to explore what uses the substance could have as a drug for severe bacterial infections in humans.

Originally, it was considered to be a drug of last resort [2] as penicillins were effective for most infections and the risk of adverse effects were higher for vancomycin than other antibacterial drugs.

Over time, however, the development of drug resistance, improvement in purification, and the advancement of drug monitoring techniques brough...