Romiplostim (Nplate) | 合法藥品大搜索

由DHubulashvili著作·2009·被引用12次—RomiplostimisanFc-peptidefusionprotein(peptibody)thatstimulatesintra-cellulartranscriptionalpathways,whichresultsinincreasedplateletproductionby ...

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder caused by an abnormally low level of platelets. In patients with ITP, antibodies against platelets are produced. The antibodies coat the platelets, causing them to be vulnerable to immediate uptake and destruction by macrophages within the spleen.

Typically, symptoms of ITP develop when platelet counts drop below 50 × 109/L. Petechiae, epistaxis, and gingival bleeding can occur. Patients may also report easy bruising and bleeding from minor wounds. Serious bleeding, including overt gastrointestinal (GI) bleeding, gross hematuria, and intracranial hemorrhage may occur; however, these events are considered infrequent. Nevertheless, serious bleeding sometimes occurs in elderly patients, and this can be significant. Bleeding can be attributed to other comorbidities and possible precipitating factors that can potentiate a bleeding episode.

The onset of thrombo...