C. elegans phototransduction requires a G protein | 合法藥品大搜索
The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein-mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photorecep...
"井田"克酸痛錠200公絲(舒林達酸) KENTON TABLETS ... | 合法藥品大搜索
"井田"好胃明膜衣錠200毫克(希每得定) HOU WE MING ... | 合法藥品大搜索
C. elegans phototransduction requires a G protein | 合法藥品大搜索
cAMP regulates nitric oxide production and ouabain sensitive ... | 合法藥品大搜索
GMP INADA | 合法藥品大搜索
Identification of Guanylyl Cyclases That Function in ... | 合法藥品大搜索
Modulation of basal nitric oxide | 合法藥品大搜索
Modulation of basal nitric oxide-dependent cyclic | 合法藥品大搜索
The Importance of cGMP Signaling in Sensory Cilia for Body ... | 合法藥品大搜索
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