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Etoposide mechanism | 合法藥品大搜索

Etoposide mechanism

,由AMontecucco著作·2015·被引用160次—Startingfrom1980sseveralstudiesdemonstratedthatetoposidetargetsDNAtopoisomeraseIIactivitiesthusleadingtotheproductionofDNAbreaksandeliciting ...,由GReyhanoglu著作·2020·被引用1次—Thisactivitywillhighlightthemechanismofaction,adverseeventprofile,andotherkeyfactors(e.g.,off-labeluses,dosing, ...,由JYang著作·2009·被引用44次—Description.Etoposideisacommonlyusedchemotherapyagentwithabroadrangeofantitumoractivity.Etoposideandteniposide,theepipodophyllot...

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Etoposide: Uses | 合法藥品大搜索
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Molecular mechanisms of etoposide | 合法藥品大搜索
由 A Montecucco 著作 · 2015 · 被引用 160 次 — Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting ... Read More
Etoposide | 合法藥品大搜索
由 G Reyhanoglu 著作 · 2020 · 被引用 1 次 — This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, ... Read More
Etoposide pathway | 合法藥品大搜索
由 J Yang 著作 · 2009 · 被引用 44 次 — Description. Etoposide is a commonly used chemotherapy agent with a broad range of antitumor activity. Etoposide and teniposide, the epipodophyllotoxins, ... Read More
Etoposide | 合法藥品大搜索
Mechanism of action — Mechanism of action[edit]. Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, which is an enzyme ... Read More
BIOCHEMICAL MECHANISMS OF ETOPOSIDE; UPSHOT OF ... | 合法藥品大搜索
2015年12月1日 — The primary mode of action of etoposide is the inhibition of the function of the enzyme topoisomerase II. It stabilizes DNA-enzyme complex, and ... Read More
Etoposide, topoisomerase II and cancer | 合法藥品大搜索
由 EL Baldwin 著作 · 2005 · 被引用 505 次 — Etoposide kills cells by stabilizing a covalent enzyme-cleaved DNA complex (known as the cleavage complex) that is a transient intermediate in the catalytic cycle ... Read More
Mechanism of action of antitumor drug etoposide | 合法藥品大搜索
由 JM van Maanen 著作 · 1988 · 被引用 349 次 — The cytotoxicity of etoposide is caused by the induction of DNA damage. The occurrence of the DNA lesions can be explained by the capacity of the drug to ... Read More
(PDF) Molecular mechanisms of etoposide | 合法藥品大搜索
Etoposide inhibits DNA re-litigation (Montecucco et al., 2015) , causing apoptosis of cells in the S phase. Errors in the DNA due to a sub-optimal re-litigation ... Read More
MOLECULAR MECHANISMS OF ETOPOSIDE | 合法藥品大搜索
由 A Montecucco 著作 · 被引用 160 次 — In this review we will focus on molecular mechanisms that account for the biological effect of etoposide. ETOPOSIDE IS A TOPOISOMERASE II. Read More
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