Mechanism of Action | 合法藥品大搜索

WatchtheCorlanor®mechanismofactionvideotolearnabouthowthetherapyworks.SeeifCorlanor®mayberightforyourchronicheartfailurepatients.

IMPORTANT SAFETY INFORMATION

Contraindications Corlanor® is contraindicated in patients with acute decompensated heart failure, clinically significant hypotension, sick sinus syndrome, sinoatrial block, 3rd degree atrioventricular block (unless a functioning demand pacemaker is present), clinically significant bradycardia, severe hepatic impairment, pacemaker dependence (heart rate maintained exclusively by the pacemaker), and concomitant use of strong cytochrome P450 3A4 (CYP3A4) inhibitors.

Fetal Toxicity  Corlanor® may cause fetal toxicity when administered to a pregnant woman based on embryo-fetal toxicity and cardiac teratogenic effects observed in animal studies. Advise females of reproductive potential to use effective contraception when taking Corlanor®.

Atrial Fibrillation  Corlanor® increases the risk of atrial fibrillation. The rate of atrial fi...