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由CGulea著作·2021·被引用3次—Conclusion.Theclasseffectofbeta-blockersremainsgenerallypositiveinpatientswithCOPD.ReducedratesofAECOPD,mortality,and ...

The database search identified 2932 potentially relevant articles whilst other sources revealed six. After title and abstract screening, 187 articles underwent full-text review. We included 23 observational studies and 14 RCTs that reported on patients with COPD, in the systematic literature review. Out of a total of 23 observational studies, 21 reported on mortality [24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44], five reported on AECOPD [24, 33, 35, 45, 46] three reported on all-cause hospitalization [47,48,49], one reported on SGRQ [45] and one reported on SF-36 [42]. From a total of 14 RCTs, 12 reported on FEV1 [50,51,52,53,54,55,56,57,58,59,60,61], two each reported on 12MWT [59, 62] and 6MWT [12, 56] and two reported on SGRQ [12, 56] (Fig. 1).

According to our protocol, we intended to include data on effect of beta-blockers on AECOPD from RCTs, however our search strategy revealed only one study of this kind [12]. Based on a population of 532...