【篤實關懷倫理卓越】光田綜合醫院Kuang Tien General Hospital | 合法藥品大搜索

商品名,CANCIDAS50MG/VIAL,藥品許可證,衛署藥輸字第023485號.中文名,黴息止注射劑,健保局藥理類別,081204抗生素－抗黴菌劑.學名,Caspofungin,外觀 ...

DistributionAbout 97% protein bound (albumin).

MetabolismSlowly metabolized by hydrolysis and N-acetylation and undergoes spontaneous chemical degradation.

EliminationThe t ½ is 9 to 11 h (beta phase) and 40 to 50 h (gamma phase). 35% is excreted in feces and 41% in urine (about 1.4% as unchanged drug). Renal Cl is about 0.15 mL/min. Total Cl is 12 mL/min. Not dialyzable.

Special PopulationsRenal Function ImpairmentAUC is increased 30% to 49% in those with Ccr up to 49 mL/min.

Hepatic Function ImpairmentMild (Child-Pugh score 5 to 6) AUC is increased about 55%.

Moderate (Child-Pugh score 7 to 9) AUC is increased 76%.

ElderlyAUC is increased about 28%. No dosage adjustment is needed.

Cyclosporine Avoid concurrent use if possible because caspofungin levels may be elevated, increasing the risk of side effects.

Inducers or mixed induce...