Eplerenone Versus Spironolactone in Resistant ... | 合法藥品大搜索

由AAManolis著作·2019·被引用11次—EplerenoneVersusSpironolactoneinResistantHypertension:anEfficacyand/orCostorJustaMen'sIssue?CurrHypertensRep.2019Mar2;21(3):22.doi: ...

Purpose of review: To review comparative efficacy and tolerability data between the two main mineralocorticoid receptor antagonists (MRAs), spironolactone and eplerenone, in patients with resistant hypertension (HTN). The focus was whether spironolactone, being the classical non-selective agent that has been used for years, albeit with several anti-androgenic side effects, can be rivaled by eplerenone, an apparently weaker, but better tolerated, more selective MRA.

Recent findings: Evidence has accumulated that resistant HTN is generally volume-dependent, attributable to varying degrees of aldosterone excess with its attendant renal effects of sodium and fluid retention. Such aldosteronism may be due to an underestimated occurrence of primary aldosteronism; however, it more commonly occurs separately from it and independent from angiotensin II. The aldosterone-induced volume excess placed at the...