Eplerenone (Inspra) | 合法藥品大搜索

由JCraft著作·2004·被引用49次—Themostseveresideeffectofspironolactone,hyperkalemia,wasalsoobservedwitheplerenone.Whileeplerenoneismoreselective,withthepotentialfor ...

Most published clinical trials evaluated the efficacy of eplerenone for the treatment of hypertension. One group of researchers, utilizing the same patient population, conducted many of the trials (referenced below). The data were manipulated to reach the desired outcomes for each clinical trial. No clinical trials directly compared eplerenone and spironolactone for either indication. Even though a few trials did have a spironolactone arm, this arm was compared only with placebo.

A multicenter, double-blind, randomized, active-controlled, titration-to-effect trial comparing eplerenone to amlodipine showed noninferiority to amlodipine by assessing mean change in seated systolic BP. Patients ≥50 years of age with hypertension (systolic BP 150–165 mm Hg/diastolic BP ≤95 mm Hg) received either eplerenone (n = 134) or amlodipine (n = 135) as follows: The initial doses were eplerenone ...