Vitamin B12 and homocysteine | 合法藥品大搜索

由BMGilfix著作·2005·被引用10次—Thereisastrongcorrelationbetweenmethylmalonicacidandhomocysteinelevels,andthesensitivityofhomocysteinelevelsforidentifyingvitaminB12deficiency ...

In examining the relationship of serum vitamin B12 levels to homocysteine levels,1 Julie Robertson and colleagues highlight the utility of homocysteine in the clinical investigation of vitamin B12 deficiency.

Both methylmalonic acid and homocysteine are elevated in vitamin B12 deficiency. The measurement of methylmalonic acid requires not readily available methods involving mass spectrometry, whereas homocysteine is readily measured in the clinical laboratory by fluorescent polarization, enzymatic assays and high-pressure liquid chromatography. There is a strong correlation between methylmalonic acid and homocysteine levels, and the sensitivity of homocysteine levels for identifying vitamin B12 deficiency is greater than 95%.2,3,4 Measurement of creatinine, folate and vitamin B12 levels and the patients response to treatment will clarify the cause of the elevated homocysteine levels. At my institution we no longer routinely offer methylmalonic acid measurement as the diagnost...