Vitamin B12 Deficiency | 合法藥品大搜索

由ROh著作·2003·被引用638次—VitaminB12deficiency,therefore,canleadtoincreasedlevelsofserummethylmalonicacid.Inthesecondreaction,homocysteineisconvertedto ...

ROBERT C. OH, CPT, MC, USA, U.S., Army Health Clinic, Darmstadt, Germany

DAVID L. BROWN, MAJ, MC, USA, Madigan Army Medical Center, Fort Lewis, Washington

Am Fam Physician. 2003 Mar 1;67(5):979-986.

  Patient Information Handout [1]

Vitamin B12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders. The role of B12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored. Diagnosis of vitamin B12 deficiency is typically based on measurement of serum vitamin B12 levels; however, about 50 percent of patients with subclinical disease have normal B12 levels. A more sensitive method of screening for vitamin B12 deficiency is measurement of serum methylmalonic a...