Nefopam as an adjunct to intravenous patient | 合法藥品大搜索

由SYKim著作·2015·被引用7次—Nefopamasanadjuncttointravenouspatient-controlledanalgesiaafterrenal...Painintensityscores,cumulativedoseoffentanyl,andtheincidenceofadverse ...

Background: Nefopam has been used as an adjuvant to opioid analgesia after operation. We investigated the efficacy of nefopam as an adjunct to fentanyl-based intravenous patient-controlled analgesia (IV PCA) on post-operative pain relief in patients undergoing renal transplantation.

Methods: Ninety-eight patients undergoing elective renal transplantation were randomised into two groups: nefopam or control groups. The former received nefopam (160 mg in 200 ml at a rate of 4 ml/h) whereas the latter received normal saline during the first 48 h after reperfusion of grafted kidney. Pain intensity scores, cumulative dose of fentanyl, and the incidence of adverse events were assessed at 1, 6, 12, 24, and 48 h post-operatively. Serum creatinine and estimated glomerular filtration rate were e...