Population pharmacokinetics of nefopam in ... | 合法藥品大搜索

由ZDjerada著作·2014·被引用27次—Asingledoseofnefopam(20mg)shouldbeinfusedoveraperiod>45mininagedpatientswithorwithoutrenalimpairment.Goto:Introduction.Elderlypeople​ ...

Elderly people undergo more surgical procedures than younger individuals 1,2, and pain in the elderly is poorly controlled 3–5; therefore, providing adequate postoperative analgesia is critical and essential. Several pharmacological agents combined according to different strategies, as in multimodal analgesia, can be used for pain management 4,6,7. Nefopam (nef) is a centrally acting non-opioid analgesic indicated for treatment of postoperative pain after abdominal, urological or orthopaedic surgery, either alone or in combination with other drugs 8–10. In contrast to opioid analgesics, nefopam has no respiratory-depressive effect 11,12 and provides a better quality of analgesia 10,13–15. After administration, nefopam is mainly metabolized by the liver; seven metabolites have been described, with only one, desmethyl-nefopam (dnef), denoting pharmacological activity and found at very low concentrations 16. The main route of elimination of the metabolites is renal 17. Nev...