The risk of seizures among the carbapenems | 合法藥品大搜索

TheORsforriskofseizuresfromimipenem,meropenem,ertapenemanddoripenemcomparedwithotherantibioticswere3.50(95%CI2.23,5.49),1.04(​95% ...

Bibliographic details: Cannon JP, Lee TA, Clark NM, Setlak P, Grim SA.  The risk of seizures among the carbapenems: a meta-analysis. Journal of Antimicrobial Chemotherapy 2014; 69(8): 2043-2055. [PubMed: 24744302[1]]

OBJECTIVES: A consensus exists among clinicians that imipenem/cilastatin is the most epileptogenic carbapenem, despite inconsistencies in the literature.

METHODS: We conducted a meta-analysis of all randomized controlled trials comparing carbapenems with each other or with non-carbapenem antibiotics to assess the risk of seizures for imipenem, meropenem, ertapenem and doripenem.

RESULTS: In the risk difference (RD) analysis, there were increased patients with seizure (2 per 1000 persons, 95% CI 0.001, 0.004) among recipients of carbapenems versus non-carbapenem antibiotics. This difference was largely attributed to imipenem as its use was associated with an additional 4 patients per 1000 with seizure (95% CI 0.002, 0.007) compared with non-carb...