Ivabradine and AF | 合法藥品大搜索

2020年2月11日—WhileforthetreatmentofstableanginawithsymptomaticHFwithreducedejectionfraction,ivabradineshouldbeconsideredasanantianginal ...

Ivabradine is a pure heart rate-lowering agent best characterised by its negative chronotropic effect on the sinoatrial node.1 Its unique mechanism selectively blocks the pacemaker funny (If) channels, which are responsible for spontaneous depolarisation in the sinoatrial node that regulates heart rate during sinus rhythm (Figure 1).2 Since 1980, it has been well established that controlling the heart rate is the main target when treating coronary artery disease (CAD) and heart failure (HF) and is associated with a beneficial effect on mortality and morbidity.3,4

Current Approved Clinical Indications

According to the European Society of Cardiology guidelines for heart failure, ivabradine should be considered in order to reduce the risk of hospitalisation due to HF or cardiovascular death in symptomatic patients with left ventricular ejection fraction (LVEF) ≤35%, a sinus rhythm and resting he...