Ivabradine and atrial fibrillation | 合法藥品大搜索

由MRCowie著作·2014·被引用6次—TheriskofdevelopingAFmaybehigherinpatientswithchronicheartfailuretreatedwithivabradine.AFhasbeenmorecommoninpatientsusingconcomitantly ...

Ivabradine selectively blocks the If channel by binding to a site in the channel pore, reducing the f-current and thereby reducing the slope of the slow diastolic depolarisation phase of the action potential in the sinoatrial node cells, increasing the time required to reach the voltage threshold for action potential initiation. This slows the spontaneous firing of the sinoatrial node cells and, therefore, the heart rate (HR). The drug is licensed for the treatment of angina and of systolic heart failure in sinus rhythm. At therapeutic doses the drug does not act on other cardiac ion currents and there appears to be no direct effects on myocardial contractility or relaxation, cardiac output, coronary haemodynamics, blood pressure or peripheral resistance in humans.

The molecular subunits of the If channel are the hyperpolarisation-activated cyclic-nucleotide gated (HCN) channels. Polymorphism in these proteins may explain some of the variation in resting HR i...