Topoisomerase Inhibitors | 合法藥品大搜索

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由 KJ Aldred 著作 · 2014 · 被引用 797 次 — Because quinolones stabilize cleavage complexes by inhibiting DNA ligation, they also impair the overall catalytic functions of gyrase and ... Read More

由 A Fàbrega 著作 · 2009 · 被引用 346 次 — As mentioned above, quinolone drugs are active against type II topoisomerases and act by blocking DNA replication and inhibiting synthesis and cell division (​Vila ... Read More

由 DC Hooper 著作 · 2016 · 被引用 163 次 — QUINOLONE MECHANISM OF ACTION. Quinolones target two essential bacterial type II topoisomerase enzymes, DNA gyrase and DNA topoisomerase IV ... Read More

Mechanism of action — The mechanisms of the toxicity of fluoroquinolones have been attributed to their interactions with different receptor complexes, ... Read More

2011年3月29日 — Fluoroquinolones act by inhibiting the activity of both the DNA gyrase and the topoisomerase IV enzymes. For most gram negative bacteria, DNA ... Read More

由 DC Hooper 著作 · 2001 · 被引用 506 次 — The fluoroquinolones are the only direct inhibitors of DNA synthesis; by binding to the enzyme-DNA complex, they stabilize DNA strand breaks created by DNA ... Read More

由 GA Jacoby 著作 · 2005 · 被引用 1000 次 — Mechanisms of resistance to quinolones. Clin Infect Dis. 2005 Jul 15;41 Suppl 2:​S120-6. doi: 10.1086 ... Read More

由 KJ Aldred 著作 · 2014 · 被引用 797 次 — As is the case with other antibacterial agents, the rise in quinolone resistance threatens the clinical utility of this important drug class. Quinolones ... Read More