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由MCMcGovern著作·2001·被引用48次—AconsistentassociationhasbeenshownbetweenReye'ssyndromeandtheuseofaspirinduringtheprodromalillness....Ofthe56childrenwithReye'ssyndrome ...

Reyes syndrome represents an abrupt, profound failure of mitochondria, the cause of which is uncertain. It is a biphasic illness, occurring mainly in childhood, which consists of an acute viral prodrome followed several days later by an acute encephalopathy associated with selective hepatic abnormality and metabolic decompensation. A consistent association has been shown between Reyes syndrome and the use of aspirin during the prodromal illness.1 Of the 56 children with Reyes syndrome treated at this centre between January 1979 and December 1986, 46 (82%) had been given aspirin. During the past 13 years just five cases have been seen—two occurred in February 1999, and in both cases the child had been given aspirin.

A boy aged 12.5 years had flu-like symptoms of mild fever, headache, and generalised aches for five days. He was given aspirin (300 mg every four hours for 24 hours) after which his symptoms seemed to resolve. However, 12 hours later he began vomiting, and t...