高血壓藥物thiazide @ 急診小醫師 | 合法藥品大搜索

thiazide-typediureticshydrochlorothiazidethiazide-likediureticsincludingindapamideandchlorthalidone在相同劑量時,indapamideandchlorthalidone降壓 ...

thiazide-type diuretics hydrochlorothiazide

thiazide-like diuretics including indapamide and chlorthalidone

在相同劑量時,  indapamide and chlorthalidone 降壓效果優於 hydrochlorothiazide

Thiazide-like versus thiazide-type diuretics — Chlorthalidone and indapamide, commonly used thiazide-like diuretics, are significantly more potent antihypertensive agents than hydrochlorothiazide, a commonly used thiazide-type diuretic, at similar dose levels [20-25]. In a meta-analysis of 14 trials that compared the blood pressure reduction with one of three dose levels of hydrochlorothiazide (low, intermediate, high) to a similar dose level of one of the thiazide-like diuretics, systolic pressure reduction was greater with chlorthalidone and indapamide (by 3.6 and 5.1 mmHg, respectively) [20].

Thiazide 利尿劑的劑量與降壓曲線比較平, 意思是小劑量與大劑量的降壓效果沒有差很多, 但使用大劑量則會提高副作用, 例如低血鉀, 血糖耐受不良, 血中尿酸濃度上升...