Tivicay 25 mg Film | 合法藥品大搜索

Eachfilm-coatedtabletcontainsdolutegravirsodiumequivalentto50mgdolutegravir.Forthefulllistofexcipients,seesection6.1.3.Pharmaceuticalform.Film- ...

Pharmacotherapeutic group: Antivirals for systemic use, other antivirals, ATC code: J05AJ03

Mechanism of action

Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle.

Pharmacodynamic effects

Antiviral activity in cell culture

The IC50 for dolutegravir in various labstrains using PBMC was 0.5 nM, and when using MT-4 cells it ranged from 0.7-2 nM. Similar IC50s were seen for clinical isolates without any major difference between subtypes; in a panel of 24 HIV-1 isolates of clades A, B, C, D, E, F and G and group O the mean IC50 value was 0.2 nM (range 0.02-2.14). The mean IC50 for 3 HIV-2 isolates was 0.18 nM (range 0.09-0.61).

Antiviral activity in combination with other antiviral agents

No antagonistic effects in vitro were seen with dolutegravir and other antiret...