Oral calcitriol versus oral alfacalcidol for the treatment of ... | 合法藥品大搜索

由SMoe著作·2008·被引用28次—Thissmallrandomizedcrossoverstudyprovidespreliminaryevidencethatequaldosesoforalalfacalcidolandcalcitriolmaydemonstrate ...

Background: Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and treatment with vitamin D analogues is a mainstay of therapy. Although oral calcitriol and alfacalcidol are used extensively in Canada, there is little published data comparing equal doses of these agents.

Objectives: To compare the effect of equal doses of oral calcitriol and alfacalcidol on intact parathyroid hormone concentrations (iPTH) in the treatment of secondary hyperparathyroidism due to chronic kidney disease. Secondary endpoints included serum 1,25-dihydroxyvitamin D3, calcium and phosphate concentrations, achievement of target iPTH concentrations, and need for phosphate binder dose increases.

Methods: Five adult hemodialysis subjects who were naA ve to vitamin D analogues and had iPTH concentrations > or = 20 pmol/L were enrolled in a prospective, randomized 1...