Randomized trial comparing pulse calcitriol and alfacalcidol ... | 合法藥品大搜索

由KKiattisunthorn著作·2011·被引用30次—Alfacalcidolcanbeusedtocontrolsecondaryhyperparathyroidismatdosesof1.5-2.0timesthatofcalcitriol.Thetwodrugsareequallyefficaciousand ...

Aim: Calcitriol and alfacalcidol are used extensively for the treatment of secondary hyperparathyroidism. Unfortunately, there is limited published data comparing the efficacy and tolerability of both active vitamin D sterols. This study was undertaken to determine whether calcitriol provides a therapeutic advantage to alfacalcidol.

Methods: This was a randomized, active controlled study. Patients with intact parathyroid hormone (iPTH) >32 pmol/L were randomized to receive orally calcitriol or alfacalcidol after each haemodialysis for up to 24 weeks. Reduction of PTH, changes of plasma albumin-corrected calcium and phosphorus were analysed. The initial dose of alfacalcidol was twice that of calcitriol.

Results: Sixteen patients were randomized into each group. At baseline, plasma albumin-corrected calcium, phosphorus and PTH were no different between groups. At 24 weeks, PTH chan...