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Mechanism of action of the new anti | 合法藥品大搜索

Mechanism of action of the new anti

Mechanism of action of the new anti

Clin Res Cardiol. 2008 Apr; 97(4): 222–226.

and G. Hasenfuss

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

L. S. Maier

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

Corresponding author.

Received 2007 May 18; Accepted 2007 Oct 18.

Abstract

Myocardial ischemia is associated with reduced ATP fluxes and decreased energy supply resulting in disturbances of intracellular ion homeostasis in cardiac myocytes. In the recent years, increased persistent (late) sodium current was suggested to contribute to disturbed ion homeostasis by elevating intracellular sodium concentration with subsequent elevation of intracellular calcium. The new anti-ischemia drug ranolazine, a specific inhibitor of late sodium curre...

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Mechanism of action of the new anti | 合法藥品大搜索
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Ranolazine | 合法藥品大搜索
由 BM Reddy 著作 · 2010 · 被引用 41 次 — Ranolazine's initial mechanism of action was thought to be the inhibition of cardiac metabolism of fatty acids. However, the concentration of the drug that ... Read More
Mechanism of Action of Ranolazine | 合法藥品大搜索
由 C Marx 著作 · 2006 · 被引用 8 次 — The proposed ranolazine mechanism of action is the inhibition of pathologic increases in late Na+ current induced during myocardial ischemia. Read More
Ranolazine: Uses | 合法藥品大搜索
The mechanism of action for ranolazine is not fully understood. At therapeutic concentrations, it can inhibit the cardiac late sodium 205 current (INa), which ... Read More
Late Sodium Current Blocker (Ranolazine) | 合法藥品大搜索
Mechanism of Action. Ranolazine represents a new class of antianginal drugs. It blocks late inward sodium currents in cardiomyocytes. Read More
Ranolazine | 合法藥品大搜索
Mechanism of action — Mechanism of action[edit]. Ranolazine inhibits persistent or late inward sodium current (INa) in heart muscle in a variety of ... Read More
mechanism of ranolazine action to reduce ischemia | 合法藥品大搜索
由 L Belardinelli 著作 · 2006 · 被引用 96 次 — Sodium channels and the action of ranolazine ... Electrical excitation causes sodium ions to enter cardiac cells through membrane sodium channels. Read More
Ranolazine Article | 合法藥品大搜索
2021年6月29日 — Mechanism of Action ... The mechanism of ranolazine's anti-anginal and anti-ischemic effects is not well understood. It inhibits late sodium ... Read More
Ranolazine | 合法藥品大搜索
2016年3月15日 — New‐Onset and Paroxysmal Atrial Fibrillation. The mechanism of action of ranolazine has been proposed to reduce atrial excitability and prolong ... Read More
Ranolazine. A metabolic modulator for the treatment of chronic ... | 合法藥品大搜索
由 JR Anderson 著作 · 2005 · 被引用 30 次 — While the mechanism of action of ranolazine is not completely understood, it is believed to involve a reduction in fatty acid oxidation, ultimately leading ... Read More
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