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Mechanism of action of the new anti | 合法藥品大搜索

Mechanism of action of the new anti

由GHasenfuss著作·2008·被引用79次—Mostspecifically,ranolazinehasbeenshowntoreversethesustainedriseindiastolicandsystoliccalciumcausedbyawell-knownenhancerof ...

 Mechanism of action of the new anti

Clin Res Cardiol. 2008 Apr; 97(4): 222–226.

and G. Hasenfuss

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

L. S. Maier

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

Dept. of Cardiology and Pneumology, Heart Center Göttingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany

Corresponding author.

Received 2007 May 18; Accepted 2007 Oct 18.

Abstract

Myocardial ischemia is associated with reduced ATP fluxes and decreased energy supply resulting in disturbances of intracellular ion homeostasis in cardiac myocytes. In the recent years, increased persistent (late) sodium current was suggested to contribute to disturbed ion homeostasis by elevating intracellular sodium concentration with subsequent elevation of intracellular calcium. The new anti-ischemia drug ranolazine, a specific inhibitor of late sodium curre...

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Ranolazine | 合法藥品大搜索
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Mechanism of action of the new anti | 合法藥品大搜索
由 G Hasenfuss 著作 · 2008 · 被引用 79 次 — Most specifically, ranolazine has been shown to reverse the sustained rise in diastolic and systolic calcium caused by a well-known enhancer of ... Read More
Ranolazine: Uses | 合法藥品大搜索
The mechanism of action for ranolazine is not fully understood. At therapeutic concentrations, it can inhibit the cardiac late sodium 205 current (INa), which ... Read More
Mechanism of Action of Ranolazine | 合法藥品大搜索
由 C Marx 著作 · 2006 · 被引用 8 次 — Although ranolazine was shown to have partial fatty acid oxidase inhibitor activity in preclinical investigations, it occurs at concentrations ... Read More
Late Sodium Current Blocker (Ranolazine) | 合法藥品大搜索
Mechanism of Action. Ranolazine represents a new class of antianginal drugs. It blocks late inward sodium currents in cardiomyocytes. Read More
mechanism of ranolazine action to reduce ischemia | 合法藥品大搜索
由 L Belardinelli 著作 · 2006 · 被引用 96 次 — An increase in diastolic wall tension compresses the vasculature and reduces nutritive blood flow, creating a positive feedback system that ... Read More
Ranolazine Article | 合法藥品大搜索
2021年6月29日 — Mechanism of Action ... The mechanism of ranolazine's anti-anginal and anti-ischemic effects is not well understood. It inhibits late sodium ... Read More
Ranolazine | 合法藥品大搜索
2016年3月15日 — Additional mechanisms of ranolazine activity have been studied such as adrenergic receptor binding and fatty acid oxidation inhibition. Read More
The antianginal agent ranolazine is a potent antiarrhythmic ... | 合法藥品大搜索
由 RA Kloner 著作 · 2011 · 被引用 35 次 — Background: The antianginal agent ranolazine (R) has shown some promise as an antiarrhythmic agent but its mechanism of action is not known. Read More
Ranolazine. A metabolic modulator for the treatment of chronic ... | 合法藥品大搜索
由 JR Anderson 著作 · 2005 · 被引用 30 次 — While the mechanism of action of ranolazine is not completely understood, it is believed to involve a reduction in fatty acid oxidation, ultimately leading ... Read More
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