Late Sodium Current Blocker (Ranolazine) | 合法藥品大搜索

Read More

由 G Hasenfuss 著作 · 2008 · 被引用 79 次 — Most specifically, ranolazine has been shown to reverse the sustained rise in diastolic and systolic calcium caused by a well-known enhancer of ... Read More

The mechanism of action for ranolazine is not fully understood. At therapeutic concentrations, it can inhibit the cardiac late sodium 205 current (INa), which ... Read More

由 C Marx 著作 · 2006 · 被引用 8 次 — Although ranolazine was shown to have partial fatty acid oxidase inhibitor activity in preclinical investigations, it occurs at concentrations ... Read More

Mechanism of Action. Ranolazine represents a new class of antianginal drugs. It blocks late inward sodium currents in cardiomyocytes. Read More

由 L Belardinelli 著作 · 2006 · 被引用 96 次 — An increase in diastolic wall tension compresses the vasculature and reduces nutritive blood flow, creating a positive feedback system that ... Read More

2021年6月29日 — Mechanism of Action ... The mechanism of ranolazine's anti-anginal and anti-ischemic effects is not well understood. It inhibits late sodium ... Read More

2016年3月15日 — Additional mechanisms of ranolazine activity have been studied such as adrenergic receptor binding and fatty acid oxidation inhibition. Read More

由 RA Kloner 著作 · 2011 · 被引用 35 次 — Background: The antianginal agent ranolazine (R) has shown some promise as an antiarrhythmic agent but its mechanism of action is not known. Read More

由 JR Anderson 著作 · 2005 · 被引用 30 次 — While the mechanism of action of ranolazine is not completely understood, it is believed to involve a reduction in fatty acid oxidation, ultimately leading ... Read More