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由蔡靜瑋著作·2009—磷酸二酯酶[Cyclicnucleotidephosphodiesterases(PDE)]在調控各式各樣的細胞功能上扮演重要角色。內皮細胞上有PDE2、PDE3、PDE4和PDE5的表現。PDE抑制劑能夠抑制PDE ...

Endothelial dysfunction is thought to play a key role in the evolution and progression of CKD and may be one major culprit for the development of cardiovascular disease. Biomarkers of endothelial dysfunction are higher in patients with CKD and correlate inversely with glomerular filtration rate. Thus, understanding of the mechanisms responsible for endothelial dysfunction in association with CKD is important for the development of novel renoprotective therapeutic strategies. Cyclic nucleotide phosphodiesterases (PDEs) play a critical role in regulating cellular functions through modulation of cyclic nucleotides, cAMP and cGMP. Endothelial cells are known to contain PDE2, PDE3, PDE4, and PDE5. Previously, a nonselective PDE inhibitor, pentoxifylline, has shown its anti-inflammatory, anti-proliferative, and anti-fibrotic effects in renal mesangial cells, tubular cells, and fibrobla...