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Ruxolitinib Benefits Some Patients with Graft | 合法藥品大搜索

Ruxolitinib Benefits Some Patients with Graft

2020年5月29日—Ruxolitinib,atargetedtherapythatpatientstakeasapill,inhibitstwoproteins,JAK1andJAK2,thatarethoughttoplayaroleinGVHD.

 Ruxolitinib Benefits Some Patients with Graft

May 29, 2020, by NCI Staff

Graft-versus-host disease can develop after a transplant of stem cells (round objects) from a donor.

Credit: iStock

Patients with blood cancers who develop graft-versus-host disease (GVHD) within the first few months after receiving a stem cell transplant and don’t respond to steroids are more likely to respond to the drug ruxolitinib (Jakafi)[1] than to other treatments, according to results from a large clinical trial.

The findings are from the first randomized clinical trial[2] of a treatment for GVHD[3] to yield positive results. And the study confirms findings from a smaller trial that, in 2019, led to the approval of ruxolitinib by the Food and Drug Administration (FDA) for some ...

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Ruxolitinib for Glucocorticoid | 合法藥品大搜索
由 R Zeiser 著作 · 2020 · 被引用 123 次 — Ruxolitinib is an oral selective inhibitor of JAK1 and JAK2 that reduces the incidence and severity of GVHD in vivo while preserving graft- ... Read More
Ruxolitinib for steroid-resistant acute GVHD | 合法藥品大搜索
2020年5月14日 — Jagasia et al convincingly demonstrate that ruxolitinib may rescue approximately half of patients with steroid-refractory acute GVHD: 1-year NRM ... Read More
Ruxolitinib for Glucocorticoid | 合法藥品大搜索
由 R Zeiser 著作 · 2020 · 被引用 123 次 — Background: Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have a ... Read More
Ruxolitinib for the treatment of steroid | 合法藥品大搜索
由 M Jagasia 著作 · 2020 · 被引用 66 次 — Ruxolitinib produced durable responses and encouraging survival compared with historical data in patients with steroid-refractory aGVHD who ... Read More
Ruxolitinib as Salvage Therapy for Chronic Graft | 合法藥品大搜索
由 B Modi 著作 · 2019 · 被引用 37 次 — Ruxolitinib, a selective JAK1/2 inhibitor, has recently gained favor as a second-line approach in patients with steroid-refractory cGVHD. ... Furthermore, we ... Read More
Evaluation of Ruxolitinib for Steroid | 合法藥品大搜索
由 H Wu 著作 · 2021 · 被引用 3 次 — Thereafter, the Ruxolitinib for the Treatment of Steroid-Refractory Acute GVHD (REACH-1) study investigated ruxolitinib in treating SR-aGVHD and ... Read More
Ruxolitinib Benefits Some Patients with Graft | 合法藥品大搜索
2020年5月29日 — Ruxolitinib, a targeted therapy that patients take as a pill, inhibits two proteins, JAK1 and JAK2, that are thought to play a role in GVHD. Read More
FDA Grants Ruxolitinib Priority Review to Treat Chronic GVHD | 合法藥品大搜索
2021年2月23日 — In the overall trial, 48% of patients had moderate chronic GVHD and 52% had severe chronic GVHD. As of May 8, 2020, 50% of the patients had ... Read More
Ruxolitinib in refractory acute and chronic graft | 合法藥品大搜索
由 VE Gómez 著作 · 2020 · 被引用 24 次 — In summary, ruxolitinib in the real life setting has been shown as an effective and safe treatment option for GVHD patients, with an ORR of 69.5 ... Read More
Coronavirus » Ruxolitinib for chronic and acute graft versus ... | 合法藥品大搜索
2020年11月11日 — These documents set out the recommendations for the use of ruxolitinib in graft versus host disease (GvHD) in the context of COVID-19. Read More
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