Side Effects of Rydapt (Midostaurin Capsules) | 合法藥品大搜索

QUESTION·lowbloodcellcounts,fever;·bruising,nosebleeds;·highbloodsugar;·infectionaroundaneedleinjection;·mouthsores;·coldsymptomssuchas ...

Midostaurin is a small molecule that inhibits multiple receptor tyrosine[1] kinases. In vitro biochemical[2] or cellular assays have shown that midostaurin or its major human active metabolites CGP62221 and CGP52421 inhibit the activity of wild type FLT3, FLT3 mutant[3] kinases (ITD and TKD), KIT (wild type and D816V mutant), PDGFRα/β, as well as members of the serine[4]/threonine[5] kinase PKC (protein kinase C) family.

Midostaurin demonstrated the ability to inhibit FLT3 receptor signaling and cell proliferation, and it induced apoptosis[6] in leukemic cells expressing ITD and TKD mutant FLT3 receptors or overexpressing wild type FLT3 and PDGF receptors. Midostaurin also demonstrated the ability to inhibit KIT signaling, cell proliferation and histamine[7] release and induce apoptosis in mast cells.